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Solid‐Phase Synthesis of Transition Metal Linked, Branched Oligonucleotides
Author(s) -
VargasBaca Ignacio,
Mitra Debbie,
Zulyniak Holly J.,
Banerjee Jay,
Sleiman Hanadi F.
Publication year - 2001
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/1521-3773(20011217)40:24<4629::aid-anie4629>3.0.co;2-s
Subject(s) - joins , oligonucleotide , dna , transition metal , solid phase synthesis , transition (genetics) , crystallography , chemistry , phase transition , combinatorial chemistry , computational biology , nanotechnology , materials science , computer science , physics , biology , biochemistry , gene , condensed matter physics , peptide , programming language , catalysis
The branched DNA structure 1 , in which a transition metal center resides at the branch point and joins two parallel DNA strands, was synthesized by a convergent solid‐phase approach. Complex 1 efficiently hybridizes with complementary DNA to generate transition metal linked DNA duplexes. This opens the door to using the geometries of transition metal complexes to direct the association of DNA into novel motifs.