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The B ‐Alkyl Suzuki–Miyaura Cross‐Coupling Reaction: Development, Mechanistic Study, and Applications in Natural Product Synthesis
Author(s) -
Chemler Sherry R.,
Trauner Dirk,
Danishefsky Samuel J.
Publication year - 2001
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/1521-3773(20011217)40:24<4544::aid-anie4544>3.0.co;2-n
Subject(s) - alkyl , coupling reaction , natural product , product (mathematics) , combinatorial chemistry , reaction conditions , chemistry , natural (archaeology) , organic chemistry , catalysis , mathematics , biology , geometry , paleontology
The development of new reactions that facilitate the creative and efficient synthesis of molecular structures with desirable properties continues to fascinate chemists. The test of a significant contribution is its acceptance over time by the scientific community. The B ‐alkyl Suzuki–Miyaura cross‐coupling reaction appears to be one such reaction. Since its disclosure by Suzuki and Miyaura in 1986, this reaction has been an attractive solution to challenging synthetic problems.