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A New Class of Modular Phosphinite–Oxazoline Ligands: Ir‐Catalyzed Enantioselective Hydrogenation of Alkenes
Author(s) -
Blankenstein Jörg,
Pfaltz Andreas
Publication year - 2001
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/1521-3773(20011203)40:23<4445::aid-anie4445>3.0.co;2-v
Subject(s) - phosphinite , enantioselective synthesis , iridium , oxazoline , chemistry , enantiomer , transfer hydrogenation , aryl , catalysis , combinatorial chemistry , alkyl , stereochemistry , ruthenium , organic chemistry
Both enantiomers are readily prepared of phosphinite–oxazoline ligands 1 from the D and L enantiomers of serine (see Scheme). Iridium complexes derived from these ligands (the structure of one complex is shown) are excellent catalysts for the enantioselective hydrogenation of unfunctionalized alkenes. R 1 =ferrocenyl, aryl; R 2 =alkyl, benzyl.