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“Cap‐Tag”—Novel Methods for the Rapid Purification of Oligosaccharides Prepared by Automated Solid‐Phase Synthesis
Author(s) -
Palmacci Emma R.,
Hewitt Michael C.,
Seeberger Peter H.
Publication year - 2001
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/1521-3773(20011203)40:23<4433::aid-anie4433>3.0.co;2-8
Subject(s) - isocyanate , amine gas treating , chemistry , reagent , oligosaccharide , combinatorial chemistry , computer science , chromatography , organic chemistry , polyurethane
React or get capped and tagged! Two capping reagents, designated A‐Tag and F‐Tag, mark unconverted oligosaccharides during automated synthesis for simple separation from the desired products. A‐Tagged molecules are removed by an isocyanate scavenger resin after reduction to the amine, and those with an F‐tag by filtration through fluorous silica gel. R=oligosaccharide.