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A Novel Electrophilic Diamination Reaction of Alkenes
Author(s) -
Li Guigen,
Wei HanXun,
Kim Sun Hee,
Carducci Michael D.
Publication year - 2001
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/1521-3773(20011119)40:22<4277::aid-anie4277>3.0.co;2-i
Subject(s) - electrophile , chemistry , stereoselectivity , acetonitrile , rhodium , catalysis , dimer , organic chemistry , medicinal chemistry
A three‐component electrophilic reaction transforms olefins into imidazoline and diamine derivatives (see scheme). Rhodium( II ) heptafluorobutyrate dimer (2 mol %) was utilized as the catalyst and N , N ‐dichloro‐ p ‐toluenesulfonamide (TsNCl 2 ) and acetonitrile as the nitrogen sources. Modest to good yields (45–82 %) and high regio‐ and stereoselectivity were achieved.