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Stereocontrolled Total Synthesis of (+)‐Altohyrtin A/Spongistatin 1
Author(s) -
Paterson Ian,
Chen David Y.K.,
Coster Mark J.,
Aceña Jose L.,
Bach Jordi,
Gibson Karl R.,
Keown Linda E.,
Oballa Renata M.,
Trieselmann Thomas,
Wallace Debra J.,
Hodgson Andrew P.,
Norcross Roger D.
Publication year - 2001
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/1521-3773(20011105)40:21<4055::aid-anie4055>3.0.co;2-h
Subject(s) - commonwealth , scholarship , total synthesis , marie curie , scarcity , stereochemistry , management , political science , business , chemistry , economics , law , european union , economic policy , microeconomics
As an exceptionally potent antimitotic macrolide , altohyrtin A/spongistatin 1 shows great promise in cancer chemotherapy but its extreme scarcity in the natural sponges has halted its further preclinical development. A highly stereocontrolled total synthesis, which exploits boron‐mediated aldol bond constructions, has been realized to provide, for the first time, a useful amount of synthetic material.