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Functionalized DNA: A New Replicable Biopolymer
Author(s) -
Thum Oliver,
Jäger Stefan,
Famulok Michael
Publication year - 2001
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/1521-3773(20011105)40:21<3990::aid-anie3990>3.0.co;2-o
Subject(s) - advice (programming) , work (physics) , library science , engineering , engineering ethics , management , sociology , computer science , mechanical engineering , economics , programming language
New DNA : By enzymatic polymerization of base‐modified nucleoside triphosphates, a functionalized DNA (fDNA; see picture) was generated in which every base bears an additional amino acid like residue, thus mimicking the functional group repertoire of peptides on a nucleic acid backbone. These modified oligonucleotides can in turn serve as templates for polymerase chain reaction amplification, thus utilizing fDNA as a novel class of biopolymers for in vitro selection techniques.