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A New Screen for Combinatorial Catalysis; On‐Bead Testing in Agarose Gel
Author(s) -
Müller Michael,
Mathers Trevor W.,
Davis Anthony P.
Publication year - 2001
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/1521-3773(20011015)40:20<3813::aid-anie3813>3.0.co;2-r
Subject(s) - bead , agarose , chemistry , nanotechnology , chromatography , computer science , combinatorial chemistry , materials science , composite material
Catalytic beads are readily distinguished from inactive controls in a method which exploits the localizing potential of a gel. A useful variant employs an acid/base indicator to detect the pH change on ester hydrolysis (see picture). Precipitation of the acidified indicator (red) creates an especially strong contrast between active and inactive beads.