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DNA Polymerase Selectivity: Sugar Interactions Monitored with High‐Fidelity Nucleotides
Author(s) -
Summerer Daniel,
Marx Andreas
Publication year - 2001
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/1521-3773(20011001)40:19<3693::aid-anie3693>3.0.co;2-o
Subject(s) - polymerase , nucleotide , dna polymerase , sugar , dna , fidelity , enzyme , chemistry , microbiology and biotechnology , gene , biochemistry , biology , engineering , telecommunications
Do enzyme–sugar interactions contribute to DNA‐polymerase fidelity? With the novel chemical probes 1 (R=CH 3 , CH 2 CH 3 , CH(CH 3 ) 2 , CH 2 CH(CH 3 ) 2 ), which are used by a DNA polymerase more selectively than the natural counterpart (R=H), insights are obtained into the influence of enzyme–sugar interactions on the selectivity of the enzyme.