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Total Synthesis of Hamigerans: Part 2. Implementation of the Intramolecular Diels–Alder Trapping of Photochemically Generated Hydroxy‐ o ‐quinodimethanes; Strategy and Completion of the Synthesis
Author(s) -
Nicolaou K. C.,
Gray David,
Tae Jinsung
Publication year - 2001
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/1521-3773(20011001)40:19<3679::aid-anie3679>3.0.co;2-t
Subject(s) - intramolecular force , epimer , trapping , diels–alder reaction , chemistry , total synthesis , photochemistry , combinatorial chemistry , organic chemistry , catalysis , biology , ecology
The synthesis of libraries of natural products is important for chemical biology studies. With this in mind, the intramolecular Diels–Alder reaction of photochemically generated hydroxy‐ o ‐quinodimethanes was used to produce the naturally occurring hamigerans 1 – 4 and several of their epimers.