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Total Synthesis of Hamigerans: Part 1. Development of Synthetic Technology for the Construction of Benzannulated Polycyclic Systems by the Intramolecular Trapping of Photogenerated Hydroxy‐ o ‐quinodimethanes and Synthesis of Key Building Blocks
Author(s) -
Nicolaou K. C.,
Gray David,
Tae Jinsung
Publication year - 2001
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/1521-3773(20011001)40:19<3675::aid-anie3675>3.0.co;2-g
Subject(s) - intramolecular force , key (lock) , trapping , chemistry , combinatorial chemistry , total synthesis , computer science , stereochemistry , biology , ecology , computer security
A streamlined and general method for the construction of benzannulated systems such as I involves the intramolecular Diels–Alder reaction of photochemically generated hydroxy‐ o ‐quinodimethanes, for example, II . The method was optimized to set the stage for the synthesis of the naturally occurring hamigerans.