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Synthesis of the (+)‐C26–C40 Domain of the Azaspiracids by a Novel Double Intramolecular Hetero‐Michael Addition Strategy
Author(s) -
Forsyth Craig J.,
Hao Junliang,
Aiguade Josep
Publication year - 2001
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/1521-3773(20011001)40:19<3663::aid-anie3663>3.0.co;2-u
Subject(s) - intramolecular force , ring (chemistry) , michael reaction , domain (mathematical analysis) , combinatorial chemistry , chemistry , computer science , political science , stereochemistry , biochemistry , mathematics , catalysis , organic chemistry , mathematical analysis
A stereocontrolled synthesis of the C26–C40 domain of the azaspiracid shellfish toxins containing the intricate FGHI ring system has been achieved by the deployment of novel methods for heterocycle synthesis (see scheme). Boc= tert ‐butoxycarbonyl, TBS= tert ‐butyldimethylsilyl.