Premium
Design and Synthesis of a Protein Catenane
Author(s) -
Yan Liang Z.,
Dawson Philip E.
Publication year - 2001
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/1521-3773(20011001)40:19<3625::aid-anie3625>3.0.co;2-q
Subject(s) - schematic , catenane , foundation (evidence) , representation (politics) , library science , chemistry , polymer science , computer science , crystallography , engineering , political science , law , organic chemistry , molecule , electronic engineering , politics
In contrast to DNA , proteins with topologically linked backbone structures have not yet been observed in Nature. We have chemically synthesized a p53 protein catenane (see schematic representation) consisting of interlocking cyclic polypeptides to demonstrate that such structures are synthetically attainable and can significantly stabilize the folded conformation of a protein.