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Nickel‐Catalyzed Homoallylation of Aldehydes in the Presence of Water and Alcohols
Author(s) -
Kimura Masanari,
Ezoe Akihiro,
Tanaka Shuji,
Tamaru Yoshinao
Publication year - 2001
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/1521-3773(20011001)40:19<3600::aid-anie3600>3.0.co;2-n
Subject(s) - acetylacetone , christian ministry , catalysis , chemistry , nickel , aqueous solution , glutaraldehyde , rhodium , organic chemistry , political science , law
Bishomoallyl alcohols are obtained with excellent 1,2‐ and 1,3‐asymmetric induction from reactions of unsymmetrical dienes with glutaraldehyde (50 % aqueous) or cyclic hemiacetals at room temperature [see for example, Eq. (1)]. These homoallylations of aldehydes in the presence of water are promoted by the catalytic system [Ni(acac) 2 ]/Et 3 B (acac=acetylacetone).