Premium
Catalytic C−C Bond Formation through Selective Activation of C−F Bonds
Author(s) -
Böhm Volker P. W.,
Gstöttmayr Christian W. K.,
Weskamp Thomas,
Herrmann Wolfgang A.
Publication year - 2001
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/1521-3773(20010917)40:18<3387::aid-anie3387>3.0.co;2-6
Subject(s) - catalysis , aryl , carbene , chemistry , ligand (biochemistry) , reagent , halide , combinatorial chemistry , medicinal chemistry , nickel , polymer chemistry , stereochemistry , organic chemistry , biochemistry , alkyl , receptor
The activation of strong sp 2 C−F bonds in catalytic C−C cross‐coupling reactions with aryl Grignard reagents under mild conditions is possible: A nickel complex bearing an N‐heterocyclic carbene ligand was identified as the most active catalyst for this reaction [Eq. (1)]. With the selective activation of aromatic C−F bonds over C−H bonds present, cross‐coupling chemistry employing aryl halides has finally overcome its most challenging hurdle with regard to catalyst activity.