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Atomic Force Microscope Studies on Condensation of Plasmid DNA with Functionalized Fullerenes
Author(s) -
Isobe Hiroyuki,
Sugiyama Sho,
Fukui Kenichi,
Iwasawa Yasuhiro,
Nakamura Eiichi
Publication year - 2001
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/1521-3773(20010917)40:18<3364::aid-anie3364>3.0.co;2-s
Subject(s) - fullerene , atomic force microscopy , plasmid , pbr322 , dna , condensation , transfection , dna condensation , nanotechnology , chemistry , materials science , biophysics , gene , biology , physics , biochemistry , organic chemistry , thermodynamics
DNA condensation by a fullerene vector has been imaged at the molecular level by atomic force microscopy (AFM); analysis of a mixture of plasmid DNA and DNA‐binding fullerene with the aid of this carbonaceous vector provided the first information on the mechanism of transfection. The picture shows AFM images of pBR322 DNA in the absence of (left) and partially condensed by the fullerene (right).