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Catalyzed Asymmetric Arylation Reactions
Author(s) -
Bolm Carsten,
Hildebrand Jens P.,
Muñiz Kilian,
Hermanns Nina
Publication year - 2001
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/1521-3773(20010917)40:18<3284::aid-anie3284>3.0.co;2-u
Subject(s) - enantioselective synthesis , scope (computer science) , nucleophile , catalysis , organic synthesis , combinatorial chemistry , aryl , chemistry , alkyl , biochemical engineering , organic chemistry , computer science , engineering , programming language
Addition and substitution reactions with carbon nucleophiles are fundamental processes in organic synthesis, and the development of general catalytic asymmetric variants thereof is still a major challenge today. In contrast to enantioselective alkyl transfer reactions, the corresponding arylations have not yet reached a high level of maturity. The existing protocols are either of no general applicability or are limited in terms of selectivity. This article summarizes established routes for catalytic asymmetric aryl transfer together with the latest developments in this area. The scope and limitations of this reaction are discussed.