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“Total Synthesis” Supramolecular Style: Design and Hydrogen‐Bond‐Directed Assembly of Ternary Supermolecules
Author(s) -
Aakeröy Christer B.,
Beatty Alicia M.,
Helfrich Brian A.
Publication year - 2001
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/1521-3773(20010903)40:17<3240::aid-anie3240>3.0.co;2-x
Subject(s) - cocrystal , hydrogen bond , ternary operation , isonicotinamide , chemistry , supramolecular chemistry , supermolecule , benzoic acid , intermolecular force , amide , crystallography , stereochemistry , molecule , organic chemistry , crystal structure , computer science , programming language
Getting the right balance between intermolecular interactions is crucial for the synthesis of supermolecules in a preconceived manner. The three‐component supermolecule (see picture) in the ternary cocrystal of 3,5‐dinitrobenzoic acid, isonicotinamide, and 4‐(dimethylamino)benzoic acid (1:1:1) assembles through a “primary” (between the stronger acid and pyridine) and a “secondary” hydrogen‐bonding interaction (between the weaker acid and amide).