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Synthesis of a Trisaccharide Library by Using a Phenylsulfonate Traceless Linker on Synphase Crowns
Author(s) -
Takahashi Takashi,
Inoue Hitoshi,
Yamamura Yuichi,
Doi Takayuki
Publication year - 2001
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/1521-3773(20010903)40:17<3230::aid-anie3230>3.0.co;2-z
Subject(s) - trisaccharide , linker , nucleophile , chemistry , sulfonate , combinatorial chemistry , glucoside , stereochemistry , organic chemistry , catalysis , computer science , medicine , programming language , sodium , alternative medicine , pathology
44 members are in the trisaccharide library synthesized by the method described here. Six differently protected glucoside building blocks were sulfonylated with 1 , coupled to the solid support 2 (a crown compound) by Pd 0 ‐catalyzed carbonylative amidation, glycosylated twice, and cleaved from the sulfonate linker with four nucleophiles.