Premium
The Use of Carbon Monoxide and Imines as Peptide Derivative Synthons: A Facile Palladium‐Catalyzed Synthesis of α ‐Amino Acid Derived Imidazolines
Author(s) -
Dghaym Rania D.,
Dhawan Rajiv,
Arndtsen Bruce A.
Publication year - 2001
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/1521-3773(20010903)40:17<3228::aid-anie3228>3.0.co;2-q
Subject(s) - synthon , palladium , chemistry , carbon monoxide , imine , catalysis , derivative (finance) , combinatorial chemistry , carbonylation , organic chemistry , business , finance
One of the most facile routes to prepare carboxylate‐substituted imidazolines is by the palladium‐catalyzed coupling of an imine, carbon monoxide, and an acid chloride. In this reaction, a peptide unit is constructed and directly incorporated into the heterocyclic core (see scheme).