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Total Synthesis of Dermostatin A
Author(s) -
Sinz Christopher J.,
Rychnovsky Scott D.
Publication year - 2001
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/1521-3773(20010903)40:17<3224::aid-anie3224>3.0.co;2-d
Subject(s) - polyene , stille reaction , cyanohydrin , polyol , convergent synthesis , key (lock) , stereochemistry , acetonide , chemistry , computer science , organic chemistry , medicine , computer security , polyurethane , catalysis , polymer , surgery , triamcinolone acetonide
An oxo‐hexaene macrolide antibiotic , dermostatin A (see picture) has been synthesized. Key features of the synthesis include the application of cyanohydrin acetonide couplings for the synthesis of the polyol portion, and the convergent introduction of the polyene segment by means of a Stille coupling.