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Color Indicators of Molecular Chirality Based on Doped Liquid Crystals
Author(s) -
van Delden Richard A.,
Feringa Ben L.
Publication year - 2001
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/1521-3773(20010903)40:17<3198::aid-anie3198>3.0.co;2-i
Subject(s) - chirality (physics) , enantiomer , imine , amine gas treating , alcohol , doping , liquid crystal , organic chemistry , materials science , chloride , chemistry , combinatorial chemistry , catalysis , physics , optoelectronics , chiral symmetry breaking , quantum mechanics , nambu–jona lasinio model , quark
A simple color test for enantiomeric excess requires no chiral auxiliaries and only microgram quantities of chiral products. The method is based on a chirality‐dependent color generation in doped LC films on formation of an imine or ester (see picture) from an amine and carbaldehyde or alcohol and acid chloride, respectively, and will enable the rapid screening of libraries of nonracemic compounds.