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Towards Synthetic Adrenaline Receptors—Shape‐Selective Adrenaline Recognition in Water
Author(s) -
Herm Michael,
Molt Oliver,
Schrader Thomas
Publication year - 2001
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/1521-3773(20010903)40:17<3148::aid-anie3148>3.0.co;2-s
Subject(s) - receptor , substituent , chemistry , molecular recognition , selectivity , dopamine , molecule , biophysics , stereochemistry , combinatorial chemistry , biochemistry , biology , neuroscience , organic chemistry , catalysis
A new rationally designed receptor molecule binds adrenaline derivatives in water. Its binding pattern (see picture) imitates the interplay of noncovalent interactions operating in the natural receptor. High shape selectivity is achieved for the slim dopamine skeleton, and leads to rejection of substrates with an α ‐substituent, such as amino acid derivatives.