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Author(s) -
Winssinger Nicolas,
Harris Jennifer L.,
Backes Bradley J.,
Schultz Peter G.
Publication year - 2001
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/1521-3773(20010903)40:17<3083::aid-anie3083>3.0.co;2-j
Subject(s) - computational biology , cover (algebra) , oligonucleotide , profiling (computer programming) , chemistry , biology , microbiology and biotechnology , computer science , gene , biochemistry , engineering , programming language , mechanical engineering
The cover picture shows a new method of arraying small molecules and its application in proteomic profiling. Each small molecule (CPK model) is tethered to a unique peptidonucleic acid (PNA) (yellow ribbon), which encodes its synthetic history. The library is screened against a sample of interest and then hybridized to an oligonucleotide microarray to determine the active compounds and/or the activity of the proteins. More details about this method are provided by Schultz and co‐workers on page 3152 ff. Artwork by Nicolas Winssinger, a co‐author.