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Aqueous One‐Pot Synthesis of Derivatized Cyclopentadienyl–Tricarbonyl Complexes of 99m Tc with an In Situ CO Source: Application to a Serotonergic Receptor Ligand
Author(s) -
Wald Joachim,
Alberto Roger,
Ortner Kirstin,
Candreia Lukas
Publication year - 2001
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/1521-3773(20010817)40:16<3062::aid-anie3062>3.0.co;2-o
Subject(s) - cyclopentadienyl complex , substituent , in situ , aqueous solution , chemistry , ligand (biochemistry) , ring (chemistry) , combinatorial chemistry , serotonergic , stereochemistry , inorganic chemistry , organic chemistry , receptor , catalysis , serotonin , biochemistry
Instant radiopharmaceuticals—just add [ 99m TcO 4 ] − in water! Half‐sandwich complexes of the type [(RCOCp) 99m Tc(CO) 3 ] (e.g. 1 ) were synthesized in a single step in water from [ 99m TcO 4 ] − . The acidification of the Cp ring by a carbonyl substituent and the use of K 2 [H 3 BCO 2 ] as a reducing agent and in situ source of CO are instrumental in the synthesis.