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Adhesion Forces between Lewis X Determinant Antigens as Measured by Atomic Force Microscopy
Author(s) -
Tromas Christophe,
Rojo Javier,
de la Fuente Jesús M.,
Barrientos Africa G.,
García Ricardo,
Penadés Soledad
Publication year - 2001
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/1521-3773(20010817)40:16<3052::aid-anie3052>3.0.co;2-q
Subject(s) - atomic force microscopy , adhesion , chemistry , biophysics , cell adhesion molecule , trisaccharide , cell adhesion , antigen , molecule , nanotechnology , microbiology and biotechnology , materials science , biochemistry , biology , immunology , organic chemistry
The adhesion forces between individual molecules of Lewis X trisaccharide antigen (Le X ) have been measured in water and in calcium solution by using atomic force microscopy (AFM, see graph). These results demonstrate the self‐recognition capability of this antigen, and reinforce the hypothesis that carbohydrate–carbohydrate interaction could be considered as the first step in the cell‐adhesion process in nature.