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A Stable DNA Duplex Containing a Non‐Hydrogen‐Bonding and Non‐Shape‐Complementary Base Couple: Interstrand Stacking as the Stability Determining Factor
Author(s) -
Brotschi Christine,
Häberli Adrian,
Leumann Christian J.
Publication year - 2001
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/1521-3773(20010817)40:16<3012::aid-anie3012>3.0.co;2-y
Subject(s) - stacking , nucleobase , hydrogen bond , duplex (building) , chemistry , dna , base pair , residue (chemistry) , nucleoside , stereochemistry , crystallography , combinatorial chemistry , molecule , organic chemistry , biochemistry
The stabilizing effect of a dG:dC base‐pair can also be imparted to a DNA duplex by a non‐hydrogen‐bonding, non‐shape‐complementary nucleoside analogue when interstrand stacking interactions come into play. This is the case, for example, with dBP, which has a bipyridyl (BP) residue as a nucleobase surrogate (the picture shows a dBP:dBP pair).