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Directed Assembly of Periodic Materials from Protein and Oligonucleotide‐Modified Nanoparticle Building Blocks
Author(s) -
Park SoJung,
Lazarides Anne A.,
Mirkin Chad A.,
Letsinger Robert L.
Publication year - 2001
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/1521-3773(20010803)40:15<2909::aid-anie2909>3.0.co;2-o
Subject(s) - streptavidin , oligonucleotide , nanoparticle , dna , nanotechnology , materials science , computer science , chemistry , biochemistry , biotin
DNA hybridization enables the three‐dimensional assembly of Au nanoparticles and streptavidin (see picture). The high‐density DNA‐modified Au nanoparticles were stable to nonspecific binding of streptavidin. Structural and melting investigations on the assemblies showed their formation was reversible.