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CH/π Attraction: The Origin of Enantioselectivity in Transfer Hydrogenation of Aromatic Carbonyl Compounds Catalyzed by Chiral η 6 ‐Arene‐Ruthenium( II ) Complexes
Author(s) -
Yamakawa Masashi,
Yamada Issaku,
Noyori Ryoji
Publication year - 2001
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/1521-3773(20010803)40:15<2818::aid-anie2818>3.0.co;2-y
Subject(s) - ruthenium , transfer hydrogenation , enantioselective synthesis , chemistry , substituent , catalysis , noyori asymmetric hydrogenation , aryl , formic acid , ligand (biochemistry) , organic chemistry , alkyl , biochemistry , receptor
The through‐space CH/π attraction between the η 6 ‐arene ligand on Ru and the carbonyl aryl substituent (see transition states in picture) plays a key role in the enantioselective transfer hydrogenation of aromatic carbonyl compounds with 2‐propanol or formic acid, catalyzed by chiral η 6 ‐arene–Ru II complexes.