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Spin‐Labeled Dendrimers in EPR Imaging with Low Molecular Weight Nitroxides
Author(s) -
Yordanov Alexander T.,
Yamada Kenichi,
Krishna Murali C.,
Mitchell James B.,
Woller Eric,
Cloninger Mary,
Brechbiel Martin W.
Publication year - 2001
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/1521-3773(20010716)40:14<2690::aid-anie2690>3.0.co;2-0
Subject(s) - dendrimer , electron paramagnetic resonance , chemistry , site directed spin labeling , spin probe , nitroxide mediated radical polymerization , radical , photochemistry , nitroxyl , nuclear magnetic resonance , polymer chemistry , organic chemistry , polymer , radical polymerization , physics , copolymer
Sixth‐generation PAMAM dendrimers labeled with 2,2,6,6‐tetramethylpiperidine‐1‐oxyl (TEMPO, shown schematically) have been synthesized and are shown to reoxidize EPR‐silent hydroxylamines to EPR‐active nitroxides. Therefore these dendrimers are potential TEMPO free radical life supporters for EPR imaging.