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Synthetic seco Forms of (−)‐Diazonamide A
Author(s) -
Li Jing,
Chen Xin,
Burgett Anthony W. G.,
Harran Patrick G.
Publication year - 2001
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/1521-3773(20010716)40:14<2682::aid-anie2682>3.0.co;2-r
Subject(s) - metabolite , chemistry , peptide , molecule , stereochemistry , computational biology , combinatorial chemistry , biochemistry , biology , organic chemistry
One bond and a water molecule separate title compound 1 from the potently bioactive peptide metabolite diazonamide A. Compositionally similar, yet topographically distinct, diazonamide A and 1 are both toxic towards cultured human cancer cells although the mechanisms underlying their actions likely differ. The quest towards completely synthetic diazonamides continues.