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Nitroglycal Concatenation: A Broadly Applicable and Efficient Approach to the Synthesis of Complex O‐Glycans
Author(s) -
Winterfeld Gottfried A.,
Schmidt Richard R.
Publication year - 2001
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/1521-3773(20010716)40:14<2654::aid-anie2654>3.0.co;2-l
Subject(s) - glycan , concatenation (mathematics) , chemistry , combinatorial chemistry , glycosylation , biochemistry , glycoprotein , mathematics , combinatorics
Base‐catalyzed glycosylations provide the basis for a new and general entry to the synthesis of mucin‐type O‐glycans. The desired α ‐linked 2‐acetamidoglycosyl amino acids B are accessible selectively starting from glycals of type A . Fmoc=9‐fluorenylmethoxycarbonyl.