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A Three‐Component Coupling Reaction of Aldehydes, Amines, and Alkynes
Author(s) -
Sakaguchi Satoshi,
Kubo Takashi,
Ishii Yasutaka
Publication year - 2001
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/1521-3773(20010702)40:13<2534::aid-anie2534>3.0.co;2-2
Subject(s) - aldehyde , alkyne , amine gas treating , imine , chemistry , coupling reaction , component (thermodynamics) , iridium , coupling (piping) , combinatorial chemistry , polymer chemistry , organic chemistry , catalysis , materials science , physics , metallurgy , thermodynamics
C−H bond activation of imines by an iridium complex is the decisive step in the three‐component coupling reaction of an aldehyde, an amine, and an alkyne [Eq. (1)]. The aldehyde and amine initially react to provide an imine, which in turn reacts with the alkyne to form the coupling product.