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Separation of Enantiomers by Extraction Based on Lipase‐Catalyzed Enantiomer‐Selective Fluorous‐Phase Labeling
Author(s) -
Hungerhoff Benno,
Sonnenschein Helmut,
Theil Fritz
Publication year - 2001
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/1521-3773(20010702)40:13<2492::aid-anie2492>3.0.co;2-8
Subject(s) - enantiomer , chemistry , lipase , residue (chemistry) , alcohol , chromatography , catalysis , organic chemistry , enzyme
No chromatography is necessary to separate a racemic alcohol into its enantiomers. A highly fluorinated acyl residue was tranferred in an enantiomer‐selective manner onto a racemic alcohol in the presence of a lipase [Eq. (1)]. The labeled enantiomer was separated from the unlabeled one by a simple but very efficient partition between fluorous and organic phases.