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Total Synthesis of Colombiasin A
Author(s) -
Nicolaou K. C.,
Vassilikogiannakis Georgios,
Mägerlein Wolfgang,
Kranich Remo
Publication year - 2001
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/1521-3773(20010702)40:13<2482::aid-anie2482>3.0.co;2-a
Subject(s) - enantiomer , total synthesis , stereochemistry , chemistry , absolute configuration
Colombian corals of the species Pseudopterogorgia elisabethae produce the title compound, colombiasin A ( 1 ). This structurally novel, biologically active tetracyclic compound has now been synthesized for the first time in racemic form. Preliminary studies toward the asymmetric total synthesis of both enantiomers indicate that the determination of the absolute stereochemistry can be expected soon.