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Quantitative Studies of Binding between Synthetic Galactosyl Ceramide Analogues and HIV‐1 Gp120 at Planar Membrane Surfaces
Author(s) -
Gu Yingmei,
LaBell Rachel,
O'Brien David F.,
Saavedra S. Scott
Publication year - 2001
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/1521-3773(20010618)40:12<2320::aid-anie2320>3.0.co;2-x
Subject(s) - human immunodeficiency virus (hiv) , ceramide , membrane , glycoprotein , chemistry , lipid bilayer , conjugated system , receptor , biophysics , biochemistry , biology , organic chemistry , virology , polymer , apoptosis
A critical spacer arm length necessary to promote efficient binding of the HIV‐1 surface glycoprotein rgp120 to several synthetic galactosyl‐conjugated lipids, reconstituted into planar lipid bilayers, was identified (see figure). This should aid the design of anti‐HIV‐1 agents based on membrane‐tethered, carbohydrate‐based receptors for gp120.