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TNA as a Potential Alternative to Natural Nucleic Acids
Author(s) -
Herdewijn Piet
Publication year - 2001
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/1521-3773(20010618)40:12<2249::aid-anie2249>3.0.co;2-i
Subject(s) - nucleic acid , rna , dna , base pair , chemistry , nucleic acid structure , nucleic acid analogue , pentose , biochemistry , computational biology , biology , genetics , nucleic acid thermodynamics , gene , fermentation
Tracing the origins of life : TNA (see picture) shows base pairing which is similar to that of pentose‐based RNA in regard to specificity, strand orientation, and pairing strength. TNA hybridizes with the natural nucleic acids RNA and DNA and is able to form hairpin structures. The potential of TNA as a genetic precursor of RNA is discussed.