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Titanocene‐Catalyzed Coupling of Amides in the Presence of Organosilanes To Form Vicinal Diamines
Author(s) -
Selvakumar Kumaravel,
Harrod John F.
Publication year - 2001
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/1521-3773(20010601)40:11<2129::aid-anie2129>3.0.co;2-2
Subject(s) - vicinal , deoxygenation , catalysis , coupling (piping) , chemistry , coupling reaction , polymer chemistry , organic chemistry , materials science , metallurgy
A sequence of reduction, deoxygenation, and coupling steps results in a remarkable reaction, which represents an important new method for the synthesis of 1,2‐diamines. The vicinal diamines are formed by the facile coupling of aromatic amides in the presence of titanocene catalysts and PhMeSiH 2 (see scheme).