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New Transmembrane Polyene Bolaamphiphiles as Fluorescent Probes in Lipid Bilayers
Author(s) -
Quesada Ernesto,
Acuña A. Ulises,
AmatGuerri Francisco
Publication year - 2001
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/1521-3773(20010601)40:11<2095::aid-anie2095>3.0.co;2-i
Subject(s) - polyene , chemistry , fluorescence , transmembrane protein , conjugated system , double bond , lipid bilayer , membrane , biochemistry , organic chemistry , physics , receptor , quantum mechanics , polymer
Inspired by Archaebacterial lipids , transmembrane probes anchor a sensing fluorescent polyene with Ångström resolution deep within a lipid layer (see figure). These new bolaamphiphiles are obtained in good yields from a double cross‐coupling between esters with a terminal acetylene group and conjugated 1, ω ‐dihalopolyenes, followed by partial reduction of the triple bond.