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Cyclohexylether δ ‐Amino Acids: New Leads for Selectivity Filters in Ion Channels
Author(s) -
Arndt HansDieter,
Knoll Andrea,
Koert Ulrich
Publication year - 2001
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/1521-3773(20010601)40:11<2076::aid-anie2076>3.0.co;2-g
Subject(s) - amino acid , gramicidin , chemistry , ion channel , ion , selectivity , permeability (electromagnetism) , biophysics , biochemistry , biology , membrane , organic chemistry , receptor , catalysis
Synthetic ion channels containing δ ‐amino acids can become cation selective! δ ‐Amino acids with a cyclohexylether unit (see structure) were combined with structural motives from gramicidin A and led to channels with a NH 4 + /K + permeability ratio of >10/1. (The current trace for an NH 4 + channel is shown.)