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Synthesis of Apoptolidinone
Author(s) -
Schuppan Julia,
Wehlan Hermut,
Keiper Sonja,
Koert Ulrich
Publication year - 2001
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/1521-3773(20010601)40:11<2063::aid-anie2063>3.0.co;2-#
Subject(s) - chemistry
A Cu I ‐mediated coupling of the northern and southern units and a ring‐size selective macrolactonization are the key steps in the convergent, first total synthesis of apoptolidinone, the aglycon of the potential antitumor compound apoptolidin. (The wavey lines in the picture are the retrosynthetic disconnections.)