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Synthesis of the Functionalized Macrocyclic Core of Proteasome Inhibitors TMC‐95A and B
Author(s) -
Lin Songnian,
Danishefsky Samuel J.
Publication year - 2001
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/1521-3773(20010518)40:10<1967::aid-anie1967>3.0.co;2-q
Subject(s) - proteasome , chemistry , total synthesis , stereochemistry , core (optical fiber) , biochemistry , materials science , composite material
An ordered assembly of four building blocks ( 2 – 5 ) forms the basis of the synthesis of 1 , which contains the core structure of TMC‐95A and B—two potent proteasome inhibitors (see scheme; TIPS=triisopropylsilyl, Cbz=benzoxycarbonyl, Boc= tert ‐butoxycarbonyl).