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Synthesis of a Cyclopropene Analogue of Ceramide, a Potent Inhibitor of Dihydroceramide Desaturase
Author(s) -
Triola Gemma,
Fabriàs Gemma,
Llebaria Amadeu
Publication year - 2001
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/1521-3773(20010518)40:10<1960::aid-anie1960>3.0.co;2-v
Subject(s) - cyclopropene , ceramide , sphingolipid , chemistry , stereochemistry , biochemistry , organic chemistry , apoptosis
The replacement of the double bond of ceramide by a cyclopropene (for example, erythro ‐ 1 ) has resulted in the first potent inhibitor of dihydroceramide desaturase, which is a key enzyme in the biosynthesis of sphingolipids.