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Kinetic Reactivity of “Higher Order Cuprates” in S N 2 Alkylation Reactions
Author(s) -
Nakamura Eiichi,
Yamanaka Masahiro,
Yoshikai Naohiko,
Mori Seiji
Publication year - 2001
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/1521-3773(20010518)40:10<1935::aid-anie1935>3.0.co;2-7
Subject(s) - cuprate , sn2 reaction , reactivity (psychology) , reagent , alkylation , moiety , chemistry , bridging (networking) , computational chemistry , medicinal chemistry , stereochemistry , organic chemistry , physics , computer science , quantum mechanics , catalysis , doping , medicine , computer network , alternative medicine , pathology
Why do higher order cyanocuprates often show higher reactivity than the classical Gilman reagent? Computational theoretical studies suggest that the key lies in the properties of the bridging [LiCNLi] + moiety in the cuprate (see scheme).