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Solid‐State Isomerization of Atropodiastereomers: Effective Diastereoselection through Polymorphic Transformations
Author(s) -
Einhorn Cathy,
Durif André,
Averbuch MarieThérèse,
Einhorn Jacques
Publication year - 2001
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/1521-3773(20010518)40:10<1926::aid-anie1926>3.0.co;2-3
Subject(s) - isomerization , diastereomer , solid state , state (computer science) , content (measure theory) , chemistry , computer science , stereochemistry , mathematics , organic chemistry , algorithm , catalysis , mathematical analysis
Diastereomeric ratios as high as 99:1 have been obtained by the solid‐state isomerization of mixtures of atropodiastereomers such as trans ‐ 1 a and cis ‐ 1 a , whereas their solution equilibration gave ratios close to 50:50.