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Highly Enantioselective Allylation of Imines with a Chiral Zirconium Catalyst
Author(s) -
Gastner Thomas,
Ishitani Haruro,
Akiyama Ryo,
Kobayashi Shū
Publication year - 2001
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/1521-3773(20010518)40:10<1896::aid-anie1896>3.0.co;2-w
Subject(s) - enantioselective synthesis , zirconium , enantiomer , catalysis , chemistry , combinatorial chemistry , organic chemistry
A new catalytic enantioselective method has been developed for the allylation of imines 1 by substituted allylstannanes 2 with chiral zirconium catalysts prepared from zirconium alkoxides and 1,1′‐bi‐2‐naphthol (BINOL) derivatives. The allylated products 3 were obtained in high yields and with excellent enantiomeric excesses. The basic concept of the reaction provides a convenient entry to various chiral building blocks.