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Fluorescent Fingerprinting of Molecular Recognition Landscapes
Author(s) -
Auer Manfred,
Graf Christine,
La Clair James J.
Publication year - 2001
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/1521-3773(20010518)40:10<1889::aid-anie1889>3.0.co;2-g
Subject(s) - conjugate , fluorescence , molecular recognition , fingerprint (computing) , molecule , chemistry , computational biology , pattern recognition (psychology) , biochemistry , biophysics , biology , computer science , artificial intelligence , physics , mathematics , organic chemistry , mathematical analysis , quantum mechanics
Through a reporter molecule containing a carbohydrate conjugate such as 1 , low‐affinity molecular interactions with lectins can be characterized (landscaped) by measuring both the cross‐sectional excitation and emission modifications of the reporter molecule (see picture). The three‐dimensional recognition pattern (fingerprint) and not the affinity is the selection criterion for molecular recognition.