Premium
Synthesis and Stability of Phosphatidylcholines Bearing Polyenoic Acid Hydroperoxides at the sn ‐2 Position
Author(s) -
Onyango Arnold N.,
Inoue Takafumi,
Nakajima Shuhei,
Baba Naomichi,
Kaneko Takao,
Matsuo Mitsuyoshi,
Shimizu Sakayu
Publication year - 2001
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/1521-3773(20010504)40:9<1755::aid-anie17550>3.0.co;2-q
Subject(s) - degree of unsaturation , chemistry , docosahexaenoic acid , phospholipid , eicosapentaenoic acid , fish oil , phosphatidylcholine , organic chemistry , polyunsaturated fatty acid , fish <actinopterygii> , fatty acid , biochemistry , membrane , biology , fishery
The antitumor and antimalarial activity of fish oils may involve the action of phospholipid hydroperoxides. Two such phosphatidylcholines, 1 and 2 , bearing the hydroperoxides of docosahexaenoic and eicosapentaenoic acids—the two major fatty acids in fish oils—have been synthesized. In spite of its high degree of unsaturation, 1 is sufficiently stable to permit its use in biological studies.