Premium
Immunosensing by a Synthetic Ligand‐Gated Ion Channel
Author(s) -
Terrettaz Samuel,
Ulrich WolfPeter,
Guerrini Remo,
Verdini Antonio,
Vogel Horst
Publication year - 2001
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/1521-3773(20010504)40:9<1740::aid-anie17400>3.0.co;2-5
Subject(s) - conductance , ion channel , lipid bilayer , electrode , ion , ligand (biochemistry) , dielectric spectroscopy , chemistry , analytical chemistry (journal) , materials science , biophysics , membrane , electrochemistry , receptor , chromatography , biochemistry , biology , physics , organic chemistry , condensed matter physics
Specific binding of an antibody to its antigen at subnanomolar concentrations has been detected electrically by impedance spectroscopy through changes in the ion‐conductance of a synthetic ligand‐gated ion channel (SLIC) in a supported lipid bilayer on a gold electrode (see picture).