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Total Synthesis of Azinomycin A
Author(s) -
Coleman Robert S.,
Li Jing,
Navarro Antonio
Publication year - 2001
Publication title -
angewandte chemie international edition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.831
H-Index - 550
eISSN - 1521-3773
pISSN - 1433-7851
DOI - 10.1002/1521-3773(20010504)40:9<1736::aid-anie17360>3.0.co;2-#
Subject(s) - computer science
A most elusive of synthetic targets , azinomycin A 1 has now been synthesized for the first time. Using a modular synthetic approach, and after considerable developmental effort, this antitumor agent has been synthesized in a stereocontrolled manner using a convergent series of fragment couplings and a final cyclization to form the structurally unique aziridino[1,2‐ a ]pyrrolidine ring system.